| Skin Biopsy: Emerging Method for Small Nerve Fiber Evaluation |
| Eun Hee Sohn |
| Department of Neurology, Chungnam National University Hospital, Daejeon, Korea |
| Corresponding Author:
Eun Hee Sohn ,Tel: +82-42-280-7882 , Fax: +82-42-252-8654, Email: seh337@daum.net |
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Received October 30, 2015 Accepted November 26, 2015 |
| Copyright 2015 by The Korean Society of Clinical Neurophysiology |
| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| ABSTRACT |
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Skin biopsy with investigation of small nerve fiber in human epidermis and dermis has been proven to be a useful method for demonstration of small fiber neuropathy. Quantification of intraepidermal nerve fiber density using anti-Protein Gene Product 9.5 (PGP 9.5) antibody is standardized method to diagnose the small fiber neuropathy. Skin biopsy method also makes it possible to differentiate the type of nerve fibers by using different antibodies. Quantification of dermal structures with different type of nerve fibers could be used to invest pathophysiologic mechanism of diseased state. |
| Key words:
Skin biopsy, Small fiber neuropathy, Intraepidermal nerve fiber |
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