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Review Article

Skin biopsy: an emerging method for small nerve fiber evaluation

Eun Hee Shon
Annals of Clinical Neurophysiology 2018;20(1):3-11.
Published online: January 31, 2018
Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
Corresponding author:  Eun Hee Shon, Tel: +82-42-280-7882, Fax: +82-42-252-8654, 
Email: seh337@daum.net
Received: 26 December 2017   • Revised: 28 December 2017   • Accepted: 28 December 2017
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Skin biopsy and staining the specimens with immuno-reactive markers has been proven to be a useful method to demonstrate the pathologic status of small nerve fibers. Quantification of intraepidermal nerve fiber density using anti-protein gene product 9.5 antibody is a standard method to diagnose small fiber neuropathy. Skin biopsy also makes it possible to differentiate the nerve fibers according to their function by using different markers. Quantification of dermal structures with different types of nerve fibers could reveal the pathophysiologic mechanism of the disease state.

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