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Ann Clin Neurophysiol > Volume 21(2); 2019 > Article
ORIGINAL ARTICLE
Ann Clin Neurophysiol. 2019; 21(2): 87-93.
Published online July 31, 2019.
doi: https://doi.org/10.14253/acn.2019.21.2.87
Reference ranges for autonomic function tests in healthy Korean adults
Kee Hong Park1  , Byoung Joon Kim2  , Sa-Yoon Kang3  , Sun-Young Oh4  , Eun Hee Sohn5  , Kyeong-jin Song5  , Jin-Hong Shin6  , Kyoung Hwa Kang6  , Eun Bin Cho7  , Heejeong Jeong7  , Hyung Lee8  , Hyun Ah Kim8  , Rock Bum Kim9  , and Ki-Jong Park7,10 
1Department of Neurology, Gyeongsang National University Hospital, Jinju, Korea
2Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea
3Department of Neurology, Jeju National University College of Medicine, Jeju, Korea
4Department of Neurology, Chonbuk National University School of Medicine, Jeonju, Korea
5Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
6Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
7Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Korea
8Department of Neurology, Keimyung University School of Medicine, Daegu, Korea
9Regional Cardiocerebrovascular Center, Gyeongsang National University Hospital, Jinju, Korea
10Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Korea
Corresponding Author: Ki-Jong Park ,Tel: +82-55-214-3810, Fax: +82-55-214-3255, Email: pkjong@gnu.ac.kr
Received November 16, 2018   Revised: December 7, 2018    Accepted December 7, 2018
ABSTRACT
Background: The standardized autonomic function test has become widely available. However, there are no reference data for this test for the Korean population. This study explored reference data for sudomotor and cardiovagal function tests for the Korean population.
Methods: The sweat volume by quantitative sudomotor axon reflex test, heart-rate response to deep breathing (HRdb), expiration:inspiration (E:I) ratio, and Valsalva ratio (VR) were measured in 297 healthy Korean volunteers aged from 20 to 69 years. Multivariate regression analysis was performed to evaluate the effects of age, sex, and body mass index on these variables. The 2.5th, 5th, 10th, 90th, 95th, and 97.5th percentile values were obtained for each investigation.
Results: The sweat volume was higher in males than in females. The HRdb and E:I ratio were negatively correlated with age, and were higher in males than in females. The VR was negatively correlated with age, but it was not correlated with sex.
Conclusions: This study has provided data on the reference ranges for sudomotor and cardiovagal function tests in healthy Korean adults.
Key words: Autonomic nervous system; Reference range, Sweating; Parasympathetic nervous system
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