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ACN : Annals of Clinical Neurophysiology

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Original Article

Reference ranges for autonomic function tests in healthy Korean adults

Kee Hong Park1orcid , Byoung Joon Kim2orcid , Sa-Yoon Kang3orcid , Sun-Young Oh4orcid , Eun Hee Sohn5orcid , Kyeong-jin Song5orcid , Jin-Hong Shin6orcid , Kyoung Hwa Kang6orcid , Eun Bin Cho7orcid , Heejeong Jeong7orcid , Hyung Lee8orcid , Hyun Ah Kim8orcid , Rock Bum Kim9orcid , Ki-Jong Park7,10orcid
Annals of Clinical Neurophysiology 2019;21(2):87-93.
Published online: July 31, 2019
1Department of Neurology, Gyeongsang National University Hospital, Jinju, Korea
2Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea
3Department of Neurology, Jeju National University College of Medicine, Jeju, Korea
4Department of Neurology, Chonbuk National University School of Medicine, Jeonju, Korea
5Department of Neurology, Chungnam National University Hospital, Daejeon, Korea
6Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
7Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Korea
8Department of Neurology, Keimyung University School of Medicine, Daegu, Korea
9Regional Cardiocerebrovascular Center, Gyeongsang National University Hospital, Jinju, Korea
10Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Korea
Corresponding author:  Ki-Jong Park, Tel: +82-55-214-3810, Fax: +82-55-214-3255, 
Email: pkjong@gnu.ac.kr
Received: 16 November 2018   • Revised: 7 December 2018   • Accepted: 7 December 2018
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Abstract

Background
The standardized autonomic function test has become widely available. However, there are no reference data for this test for the Korean population. This study explored reference data for sudomotor and cardiovagal function tests for the Korean population.
Methods
The sweat volume by quantitative sudomotor axon reflex test, heart-rate response to deep breathing (HRdb), expiration:inspiration (E:I) ratio, and Valsalva ratio (VR) were measured in 297 healthy Korean volunteers aged from 20 to 69 years. Multivariate regression analysis was performed to evaluate the effects of age, sex, and body mass index on these variables. The 2.5th, 5th, 10th, 90th, 95th, and 97.5th percentile values were obtained for each investigation.
Results
The sweat volume was higher in males than in females. The HRdb and E:I ratio were negatively correlated with age, and were higher in males than in females. The VR was negatively correlated with age, but it was not correlated with sex.
Conclusions
This study has provided data on the reference ranges for sudomotor and cardiovagal function tests in healthy Korean adults.

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