| Can pursuit eye movements reflect the efficacy of antiepileptic drugs? |
| Si Eun Kim, and Kang Min Park |
| Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea |
| Corresponding Author:
Kang Min Park ,Tel: +82-51-797-1195, Fax: +82-51-797-1196, Email: smilepkm@hanmail.net |
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Received August 10, 2016 Revised: November 21, 2016 Accepted November 23, 2016 |
| Copyright © 2017 The Korean Society of Clinical Neurophysiology |
| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium,
provided the original work is properly cited. |
| ABSTRACT |
Background: We evaluated whether eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy.
Methods: Thirty patients with epilepsy of unknown cause as well as age- and sex-matched normal controls were enrolled in this study. We divided the patients into drug-controlled epilepsy (n = 22) and drug-resistant epilepsy (n = 8) groups according to their seizure controls. We analyzed the differences in the parameters of the eye movements in these two groups compared with normal controls using video-based electro-oculography. In addition, we investigated the differences in the cerebellar volumes of these two groups using whole-brain T1-weighted images.
Results: The latency and accuracy of saccade in patients with epilepsy were significantly different from normal controls, but they were not different between patients with drug-controlled epilepsy and drug-resistant epilepsy. However, the gain of pursuit was significantly decreased in patients with drug-resistant epilepsy compared with normal controls (p = 0.0010), whereas it was not different between patients with drug-controlled epilepsy and normal controls (p = 0.9646). In addition, the patients with drug-resistant epilepsy had lower cerebellar volumes than normal controls (p = 0.0052), whereas the cerebellar volumes in patients with drug-controlled epilepsy were not different from normal controls (p = 0.5050).
Conclusions: We demonstrated that pursuit eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy, a finding that may be related to cerebellar dysfunction. |
| Key words:
Epilepsy; Eye movements; Anticonvulsants; Cerebellum |
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