| Home | E-Submission | Sitemap | Editorial Office |  
Ann Clin Neurophysiol > Volume 19(1); 2017 > Article
Ann Clin Neurophysiol. 2017; 19(1): 20-37.
Published online January 26, 2017.
doi: https://doi.org/10.14253/acn.2017.19.1.20
Can pursuit eye movements reflect the efficacy of antiepileptic drugs?
Si Eun Kim, and Kang Min Park
Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
Corresponding Author: Kang Min Park ,Tel: +82-51-797-1195, Fax: +82-51-797-1196, Email: smilepkm@hanmail.net
Received August 10, 2016   Revised: November 21, 2016    Accepted November 23, 2016
Copyright © 2017 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: We evaluated whether eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy.
Methods: Thirty patients with epilepsy of unknown cause as well as age- and sex-matched normal controls were enrolled in this study. We divided the patients into drug-controlled epilepsy (n = 22) and drug-resistant epilepsy (n = 8) groups according to their seizure controls. We analyzed the differences in the parameters of the eye movements in these two groups compared with normal controls using video-based electro-oculography. In addition, we investigated the differences in the cerebellar volumes of these two groups using whole-brain T1-weighted images.
Results: The latency and accuracy of saccade in patients with epilepsy were significantly different from normal controls, but they were not different between patients with drug-controlled epilepsy and drug-resistant epilepsy. However, the gain of pursuit was significantly decreased in patients with drug-resistant epilepsy compared with normal controls (p = 0.0010), whereas it was not different between patients with drug-controlled epilepsy and normal controls (p = 0.9646). In addition, the patients with drug-resistant epilepsy had lower cerebellar volumes than normal controls (p = 0.0052), whereas the cerebellar volumes in patients with drug-controlled epilepsy were not different from normal controls (p = 0.5050).
Conclusions: We demonstrated that pursuit eye movements could reflect the efficacy of antiepileptic drugs in patients with epilepsy, a finding that may be related to cerebellar dysfunction.
Key words: Epilepsy; Eye movements; Anticonvulsants; Cerebellum
PDF Links  PDF Links
Download Citation  Download Citation
Related article
Editorial Office
Department of Neurology, Gyeongsang National University Changwon Hospital,
11, Samjeongja-ro, Seongsan-gu, Changwon-si, Gyeongsangnam-do, Republic of Korea
TEL : +82-10-3396-7312    FAX : +82-82-55-214-2638   E-mail: acn.journal@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Korean Society of Clinical Neurophysiology.           Developed in M2PI