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Ann Clin Neurophysiol. 2000; 2(2): 107-113.
Upper Motor Neuron Involvement in Motor Neuron Disease: Motor Evoked Potentials Study
Sung Hun Kim, Kyung-Seok Park, Joo-Yong Kim, and Kwang-Woo Lee
Copyright © 2000 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background & Objectives : Motor evoked potentials(MEPs) to magnetic trans cranial stimulation were performed to evaluate upper moror neuron involvement and relationship to lower motor neuron involvement in motor neuron disease patients. Method : MEPs were obtained in the 17 consecutive patients with motor neuron disease. These patients were divided into three group based on clinical evidence of upper and lower motor neuron involvement, bulbar symptom; amyotrophic lateral sclerosis(ALS), progressive muscular atrophy(PMA), Progressive bulbar palsy(PBP), MEPs were recorded from abductor pollicis brevis and abductor hallucis. Abnormal MEPs were defined by delayed central motor conduction time or absent MEP. Results : MEPs were abnormal in 64%(11/17) of patients; 100%(7/7) in ALS, 64%(4/7) in PMA, 0%(0/3) in PBP respectively. In 68 total recording muscles, 34 muscles had evidence of motor weakness and showed abnormal responses in 59%(20/34). Whereas 34 muscles with normal strength, only 3%(1/34) of muscles showed abnormal responses. Conclusion : MEPs are well correlated with upper motor neuron signs in ALS and may detect masking upper motor neuron signs I PMA. The muscles with lower motor neuron sign(weakness) usually relate with abnormal MEPs reponses.
Key words: Amyotrophic lateral sclerosis, Motor evoked potential, Upper motor neuron
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