High median nerve injury, defined as injury above the elbow, is very rare and characterized by flexion weakness of thumb and index finger and abnormal palmar sensation. Schwannoma of median nerve is rare and it usually causes no symptom or paresthesia only because it grows slowly. A 54-year-old woman experienced pain and weakness of the left thumb and index finger after a surgery of schwannoma removal at the left axilla. This case illustrates the clinical feature of high median nerve injury.