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Ann Clin Neurophysiol > Volume 21(2); 2019 > Article
CASE REPORT
Ann Clin Neurophysiol. 2019; 21(2): 113-116.
Published online July 31, 2019.
doi: https://doi.org/10.14253/acn.2019.21.2.113
Uncommon coexistence of myasthenia gravis and amyotrophic lateral sclerosis
Eun Bin Cho1,2  , Tae-won Yang1  , Heejeong Jeong1  , Changhyo Yoon1  , Seunguk Jung1,2  , and Ki-Jong Park1,2 
1Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Korea
2Department of Neurology, Gyeongsang Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju, Korea
Corresponding Author: Ki-Jong Park ,Tel: +82-55-214-3810, Fax: +82-55-214-2638, Email: pkjong@gnu.ac.kr
Received June 7, 2019   Revised: June 23, 2019    Accepted July 8, 2019
ABSTRACT
Myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS) are distinct disorders. ALS affects motor neurons that control muscle movement, while MG controls communication between neurons and muscles, which occurs at neuromuscular junctions. However, on rare occasions, ALS develops after MG and vice versa. The coexistence of the two diseases represents a diagnostic challenge and requires thoughtful interpretation of clinical features. We present the case of a 53-year-old Korean male who developed ALS after MG, confirmed by clinical and electrophysiological follow-up.
Key words: Myasthenia gravis; Amyotrophic lateral sclerosis; Overlap
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