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Ann Clin Neurophysiol > Volume 21(2); 2019 > Article
CASE REPORT
Ann Clin Neurophysiol. 2019; 21(2): 108-112.
Published online July 31, 2019.
doi: https://doi.org/10.14253/acn.2019.21.2.108
Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin’s lymphoma
Hyoshin Son1  , Jongsuk Choi2  , Sung Un Kim2  , and Kyung Seok Park2 
1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
2Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
Corresponding Author: Kyung Seok Park ,Tel: +82-31-787-7466, Fax: +82-31-787-4059, Email: kpark78@naver.com
Received March 27, 2019   Revised: July 1, 2019    Accepted July 2, 2019
ABSTRACT
Non-Hodgkin’s lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.
Key words: Paraneoplastic syndrome; Occult malignancy; Demyelinating diseases; Non-Hodgkin lymphoma; Diffuse large B-cell lymphoma
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