| Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin’s lymphoma |
Hyoshin Son1 
, Jongsuk Choi2
, Sung Un Kim2
, and Kyung Seok Park2
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1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
2Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea |
| Corresponding Author:
Kyung Seok Park ,Tel: +82-31-787-7466, Fax: +82-31-787-4059, Email: kpark78@naver.com |
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Received March 27, 2019 Revised: July 1, 2019 Accepted July 2, 2019 |
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| ABSTRACT |
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Non-Hodgkin’s lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy. |
| Key words:
Paraneoplastic syndrome; Occult malignancy; Demyelinating diseases; Non-Hodgkin lymphoma; Diffuse large B-cell lymphoma |
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