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Ann Clin Neurophysiol > Volume 21(1); 2019 > Article
Ann Clin Neurophysiol. 2019; 21(1): 30-35.
Published online January 29, 2019.
doi: https://doi.org/10.14253/acn.2019.21.1.30
Prognosis of patients with postural tachycardia syndrome: a follow-up study
Sa-Yoon Kang  , Hong Jun Kim  , and Keun Hyuk Ko 
Department of Neurology, Jeju National University School of Medicine, Jeju, Korea
Corresponding Author: Sa-Yoon Kang ,Tel: +82-64-754-8175, Fax: +82-64-717-1630, Email: neurokang@jejunu.ac.kr
Received June 26, 2018   Revised: December 20, 2018    Accepted December 25, 2018
Background: Postural tachycardia syndrome (POTS) refers to the presence of orthostatic intolerance symptoms associated with a heart rate increment of greater than 30 beats/min, usually up to 120 beats/min, on head-up tilt test. Symptoms related to POTS are usually lightheadedness, palpitations and tremor, but syncope can also occur. The pathophysiology of POTS is heterogeneous and its prognosis is uncertain.
Methods: We prospectively evaluated patients who met the criteria for POTS, at baseline and follow-up, using composite autonomic symptom scores and autonomic tests to assess the autonomic function. We compared the clinical and autonomic test results between baseline and follow-up.
Results: Sixty-eight patients met the inclusion criteria for POTS and forty-five patients were ultimately followed up for at least 1 year after baseline. The patients were predominantly young females (84%), with a mean age of 21 years. Most patients showed improved orthostatic symptoms and more than a quarter of patients had no longer met the criteria for POTS at follow-up.
Conclusions: Most patients had a benign outcome in that they could resume their daily activities without great limitations. Our results demonstrated a relatively favorable prognosis in most patients with POTS.
Key words: Autonomic nervous system; Orthostatic intolerance; Postural tachycardia syndrome; Prognosis
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