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Ann Clin Neurophysiol. 2018; 20(1): 41-43.
Published online January 31, 2018.
doi: https://doi.org/10.14253/acn.2018.20.1.41
Intermediate syndrome after dermal exposure to organophosphate insecticide
Su Bin Lee, Seung Ho Ryu, Doo Yong Park, Jong-Ho Park, and Jee Young Kim
Department of Neurology, Myongji Hospital, Seonam University College of Medicine, Goyang, Korea
Corresponding Author: Jee Young Kim ,Tel: +82-31-810-6130 , Fax: +82-31-969-0500 , Email: nrkjy55@gmail.com
Received June 13, 2017   Revised: November 19, 2017    Accepted December 7, 2017
Copyright © 2018 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Intermediate syndrome (IMS) typically occurs at 24–96 hours following organophosphate (OP) poisoning, after an acute cholinergic crisis, but before OP-induced delayed polyneuropathy. It is characterized by proximal muscle weakness and respiratory insufficiency, which is a major contributing factor of OP-related morbidity and mortality. We report an atypical IMS case showing rapid-onset ascending paralysis and respiratory disturbance with an acute cholinergic crisis occurring 4–5 days after skin exposure to OP.
Key words: Organophosphate poisoning; Respiratory insufficiency; Cholinergic
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