Lennox-Gastaut syndrome associated with dysgenesis of corpus callosum

Janati, A.Bruce; ALGhasab, Naif Saad; Umair, Muhammad; , FazelHaq; Osman, Aboubaker; Sammour, Mohammad; Ahmed, AmalAbdulgadir; Ghorbel, Sofiane; Alshammeri, Hesse; Aldaife, Maram; Abdollah, Ahmad; ALMubaddel, Afnan Ibrahim

doi:2018.20.1.36

Ann Clin Neurophysiol > 2018 ;20(1) > Article

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Ann Clin Neurophysiol. 2018; 20(1): 36-40.
Published online January 31, 2018.
doi: https://doi.org/10.14253/acn.2018.20.1.36

Lennox-Gastaut syndrome associated with dysgenesis of corpus callosum

A.Bruce Janati¹, Naif Saad ALGhasab², Muhammad Umair³, FazelHaq ⁴, Aboubaker Osman⁴, Mohammad Sammour⁵, AmalAbdulgadir Ahmed⁵, Sofiane Ghorbel⁶, Hesse Alshammeri⁴, Maram Aldaife⁴, Ahmad Abdollah⁴, and Afnan Ibrahim ALMubaddel⁷

¹Department of Neurology, Center for Neurology, Fairfax, VI, USA
²Department of Internal Medicine, King Faisal Specialist Hospital, Hail University, Riyadh, Kingdom of Saudi Arabia
³Dow Medical College, Karachi, Pakistan
⁴Department of Internal Medicine, King Khaled Hospital, Hail, Kingdom of Saudi Arabia
⁵Department of Pediatrics, King Khaled Hospital, Hail, Kingdom of Saudi Arabia
⁶Center for Rehabilitation, King Khaled Hospital, Hail, Kingdom of Saudi Arabia
⁷Speclaist in Autism and Behavioral Disorder at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia

Corresponding Author: Naif Saad ALGhasab ,Tel: +966-507886878 , Fax: +966-165397403 , Email: dr.legend@hotmail.com

Received March 4, 2017 Revised: December 25, 2017 Accepted December 27, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

ABSTRACT

Lennox-Gastaut syndrome (LGS) is an electro-clinical syndrome composed of the triad of mental retardation, multiple seizure types, and the characteristic generalized slow spike-wave complexes in the electroencephalogram. In this article, we report on two patients with LGS whose brain magnetic resonance imaging showed dysgenesis of corpus callosum (CC). We discuss the role of CC in the genesis of secondary bilateral synchrony.

Key words: Epilepsy; Slow spike-wave complexes; Secondary bilateral synchrony