Abstract
In facioscapulohumeral muscular dystrophy (FSHD), prominent inflammatory cellular infiltrates mimicking inflammatory myopathies are often observed in muscle biopsies. We report extensive inflammatory changes in a 16-year-old girl who was genetically confirmed as to have FSHD. Immunohistochemical staining revealed that this could be clearly distinguished from inflammatory myopathies, both in terms of cell subsets and the expression of antigenic targets. Our observations strongly suggest that the inflammatory cellular infiltrates in FSHD differ from those observed in inflammatory myopathies.
Citations
Citations to this article as recorded by
- The DUX4 protein is a co‐repressor of the progesterone and glucocorticoid nuclear receptors
Julieta Quintero, Nizar Y. Saad, Sabrina M. Pagnoni, Daniela K. Jacquelin, Laura V. Gatica, Scott Q. Harper, Alberto L. Rosa
FEBS Letters.2022; 596(20): 2644. CrossRef - Interaction between mesenchymal stem cells and myoblasts in the context of facioscapulohumeral muscular dystrophy contributes to the disease phenotype
Ekaterina Kiseleva, Olesya Serbina, Anna Karpukhina, Vincent Mouly, Yegor S. Vassetzky
Journal of Cellular Physiology.2022; 237(8): 3328. CrossRef - Facioscapulohumeral muscular dystrophy: genetics, gene activation and downstream signalling with regard to recent therapeutic approaches: an update
Teresa Schätzl, Lars Kaiser, Hans-Peter Deigner
Orphanet Journal of Rare Diseases.2021;[Epub] CrossRef
