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Ann Clin Neurophysiol > Volume 19(2); 2017 > Article
Ann Clin Neurophysiol. 2017; 19(2): 79-92.
Published online July 24, 2017.
doi: https://doi.org/10.14253/acn.2017.19.2.79
Paraproteinemic neuropathy
So Young Pyun1  , and Byung-Jo Kim2 
1Department of Neurology, National Police Hospital, Seoul, Korea
2Department of Neurology, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Byung-Jo Kim ,Tel: +82-2-920-6619, Fax: +82-2-925-2472 , Email: nukbj@korea.ac.kr
Received October 25, 2016   Revised: March 19, 2017    Accepted May 12, 2017
Copyright © 2017 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Paraproteinemia is caused by a proliferation of monoclonal plasma cells or B lymphocytes. Approximately 10% of idiopathic neuropathies are associated with paraproteinemia, where a certain paraprotein acts like an antibody targeted at constituents of myelin or axolemma in peripheral nerves. The relationship between paraproteinemia and peripheral neuropathy remains unclear despite this being of interest for a long time. Neurologists frequently find paraproteinemia during laboratory examinations of patients presenting with peripheral neuropathy, especially in the elderly. The possibility of a relationship with paraproteinemia should be considered in cases without an explainable cause. We review the causal association between paraproteinemia and neuropathy as well as clinical, laboratory, and electrophysiologic features, and the treatment options for paraproteinemic neuropathy.
Key words: Monoclonal gammopathy; Paraproteins; Peripheral neuropathy; POEMS Syndrome; Multiple myeloma; Waldenstrom macroglobulinemia
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