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Ann Clin Neurophysiol > Volume 18(1); 2016 > Article
Ann Clin Neurophysiol. 2016; 18(1): 18-20.
Published online June 30, 2016.
doi: https://doi.org/10.14253/kjcn.2016.18.1.18
Myelin Water Fraction MRI in a Case of Clinically Probable Amyotrophic Lateral Sclerosis
Jiwon Yang1, Jongho Lee2, EungYeop Kim3, and Dong Hoon Shin1
1Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea
2Laboratory for Imaging Science and Technology (LIST), Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea
3Department of Radiology, Gachon University Gil Medical Center, Incheon, Korea
Corresponding Author: Dong Hoon Shin ,Tel: +82-32-460-3346, Fax: +83-32-460-3344, Email: dr.donghoon.shin@gmail.com
Received January 7, 2016    Accepted May 9, 2016
Copyright © 2016 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that clinically manifests both upper and lower motor neuron signs. However, it is unknown where and how the motor neuron degeneration begins, and conflicting hypotheses have been suggested. Recent advanced radiological techniques enable us to look into ALS neuropathology in vivo. Herein, we report a case with upper motor neuron-predominant ALS in whom the results of brain magnetic resonance imaging (MRI) and myelin water fraction MRI suggest axonal degeneration.
Key words: Amyotrophic lateral sclerosis, Magnetic resonance imaging, Pathology
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