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Ann Clin Neurophysiol > Volume 17(2); 2015 > Article
Ann Clin Neurophysiol. 2015; 17(2): 45-52.
Published online December 31, 2015.
doi: https://doi.org/10.14253/kjcn.2015.17.2.45
Clinical and Electrophysiologic Characteristics of Paraproteinemic Neuropathy
So Young Pyun1, and Byung-Jo Kim2
1Department of Neurology, National Police Hospital, Seoul, Korea
2Department of Neurology, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Byung-Jo Kim ,Tel: +82-2-920-6619, Fax: +82-2-925-2472, Email: nukbj@korea.ac.kr
Received October 24, 2015    Accepted November 26, 2015
Copyright 2015 by The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The paraproteinemia is a disorder in which a single clone of plasma cells (monoclonal gammopathy) is responsible for the proliferation of monoclonal proteins (M-proteins). Approximately 10% of patients with idiopathic peripheral neuropathy have monoclonal gammopathy. Some M-proteins have the properties of an antibody to the components of peripheral nerve myelin, but the pathophysiological relationship between the neuropathy and the M-protein is often obscure. The relationship between peripheral neuropathy and monoclonal gammopathy requires the appropriate neurological and hematological investigations for precise diagnosis and treatment. In this review, we provide an update on the causal associations between peripheral neuropathy and monoclonal gammopathy as well as characteristics of clinical and electrophysiologic features.
Key words: Paraproteinemic neuropathy, Monoclonal gammopathy, Polyneuropathy, Diagnosis, Treatment
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