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Ann Clin Neurophysiol > Volume 16(1); 2014 > Article
ORIGINAL ARTICLE
Ann Clin Neurophysiol. 2014; 16(1): 8-14.
Published online June 30, 2014.
doi: https://doi.org/10.14253/kjcn.2014.16.1.8
Peripheral Nerve Abnormalities in Patients with Newly Diagnosed Type I and II Diabetes Mellitus
Sang-Soo Lee1, Heon-Seok Han2, and Heon Kim3
1Departments of Neurology, Chungbuk National University School of Medicine, Cheongju, Korea
2Departments of Pediatrics, Chungbuk National University School of Medicine, Cheongju, Korea
3Departments of Preventive Medicine, Chungbuk National University School of Medicine, Cheongju, Korea
Corresponding Author: Sang-Soo Lee ,Tel: +82-43-269-6336, Fax: +82-43-275-7591, Email: pnsdoctor@gmail.com
Received October 8, 2013    Accepted February 5, 2014
Copyright © 2014 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Background: Early detection of neuropathy may prevent further progression of this complication in the diabetic patients. The purpose of this study was to evaluate the prevalence of early neuropathic complication in patients with newly diagnosed type 1 and type 2 diabetes.
Methods:
Nerve conduction studies (median, ulnar, posterior tibial, peroneal, and sural nerves) were performed for 49 type 1 (27 males, mean 14.1±7.5 years) and 40 type 2 (27 males, 42.0±14.1 years) diabetic patients at onset of diabetes. Children with age at onset under 4 years and adults over 55 years were excluded to eliminate the aging effect and the influence of obstructive arteriosclerosis. Neuropathy was defined as abnormal nerve conduction findings in two or more nerves including the sural nerve.
Results:
Mean HbA1c level was 12.6±3.3% for type 1 and 10.5±2.9% for type 2 diabetes. The prevalence of neuropathy was 12.2% for type 1, and 35.0% for type 2 diabetes, respectively. There were significant trends in the prevalence of neuropathy with increasing age (p<0.05). The effect of the mean level of glycosylated hemoglobin on the prevalence of polyneuropathy at onset of diabetes was borderline (p=0.0532). Neither sex of the patients nor the type of diabetes affected the neurophysiologic abnormalities at the diagnosis.
Conclusions:
Even in a population with diabetes at the diagnosis, the prevalence of subclinical neuropathy was not low. Neuropathy has been significantly associated with increasing age indicating the possibility of longer duration of undetected diabetes among them, especially in type 2 diabetes.
Key words: Diabetes mellitus, Diabetic polyneuropathy, Prevalence, Type 1 diabetes, Type 2 diabetes, Nerve conduction study
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