| Role of Diffusion-Weighted Imaging as a Prognostic Indicator in Acute Hypoxic Encephalopathy |
| Jin-Soo Kim1,2, Won-Young Noh1, Jae-Sung Lim3, Seon-Jeong Kim4, Chang-Ho Yun1,2, and Seong-Ho Park1,2 |
1Department of Neurology, Seoul National University College of Medicine, Seoul, Korea
2Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea
3Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea
4Department of Neurology, Howard Hill Hospital, Yongin, Korea |
| Corresponding Author:
Seong-Ho Park ,Tel: +82-31-787-7461, Fax: +82-31-787-4059, Email: nrpsh@snu.ac.kr |
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Received January 14, 2013 Accepted August 16, 2013 |
| Copyright © 2013 The Korean Society of Clinical Neurophysiology |
| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium,
provided the original work is properly cited. |
| ABSTRACT |
Background: Diffusion-weighted image (DWI) might be useful to predict the prognosis of acute hypoxic encephalopathy. The aim of our study was to test whether the early change and extent of DWI abnormalities can be an indicator of the clinical outcome of hypoxic encephalopathy.
Methods: Forty-four patients who were diagnosed as hypoxic encephalopathy due to the cardiorespiratory arrest were retrospectively identified. Clinical variables were determined, and the DWI abnormalities were counted by four areas: cortex, subcortical white matter, cerebellum and deep grey matter, and were divided into three groups by the extent of lesions. Prognosis was classified as 'poor' (Glasgow coma scale (GSC) at 30 days after arrest <9 or death) and 'good' (GSC at 30 days after arrest ≥9).
Results: GCS at day 3 (p<0.001), presence of seizure (p=0.01), and presence of lesion (p<0.001) were significantly different in prognosis, but statistically there is no association with the extent of lesions and prognosis (p=0.26).
Conclusions: Presence of early DWI changes could predict the clinical outcome of hypoxic encephalopathy after cardiorespiratory arrest. |
| Key words:
Hypoxic encephalopathy, Diffusion-weighted image, Prognosis |
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