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Case Report

Leprous Neuropathy Associated with Predominant Proprioceptive Sensory Loss

Tae-Kwan Yoon1, Hee-Young Jo2, Ji-Won Yuk2, Jin-Hong Shin2,3, Dae-Seong Kim1,2,3
Korean Journal of Clinical Neurophysiology 2013;15(1):19-23.
Published online: June 30, 2013
1Pusan National University School of Medicine, Busan, Korea
2Department of Neurology, Pusan National University Yangsan Hospital, Busan, Korea
3Reseach Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Busan, Korea
Corresponding author:  Dae-Seong Kim, Tel: +82-55-360-2450, Fax: +82-55-360-2152, 
Email: dskim@pusan.ac.kr
Received: 21 January 2013   • Accepted: 4 June 2013
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Some patients with leprosy may present with atypical features, such as isolated peripheral neuropathy without skin lesions, or marked proprioceptive dysfunction. We report a 56-year-old female who presented with predominant proprioceptive loss without skin lesion, but was finally confirmed as leprous neuropathy by sural nerve biopsy. It is postulated that large myelinated fibers were affected by chronic immunological reactions triggered by inactive bacterial particles, producing a peripheral neuropathy presenting as predominant proprioceptive sensory loss without typical skin lesions.

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