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Case Report

Statin-Induced Autoimmune Necrotizing Myopathy Responsive toImmunosuppressive Therapy

Young-Eun Park, Jae-Deuk Seo, Dae-Seong Kim
Journal of the Korean Society of Clinical Neurophysiology 2012;14(2):76-79.
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Statin is commonly used for lowering cholesterols and can be myotoxic to cause drug-induced necrotizing myopathy. Statininducedmyopathy ranges from asymptomatic hyperCKemia to lethal rhabdomyolysis but is usually reversed by withdrawalof causative drugs. The patient in this study presented with statin-induced necrotizing myopathy, which was finally improvedwith immunosuppressive therapy, but not just with drug withdrawal. Since statin can induce myopathy through autoimmuneprocesses, we should consider using immunomodulating agents in cases with statin-induced myopathy, which is refractoryto drug withdrawal.

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