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Ann Clin Neurophysiol > Volume 13(1); 2011 > Article
Ann Clin Neurophysiol. 2011; 13(1): 21-25.
Periodic Lateralized Epileptiform Discharges Are lctal Phenomena,and Need an Antiepileptic Treatment
Jae Moon Kim
Copyright © 2011 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Periodic lateralized epileptiform discharges (PLEDs) had been debated whether it is ictal or non-ictal phenomenon. As mostof PLEDs occur in patients with acute structural lesions, some epileptologists prefer PLEDS as a non-ictal phenomenon,rather an obscure epiphenomenon of etiological diseases. But, almost half of the patients with PLEDs do not have acutestructural lesions in the brain and metabolic disorders or old CNS lesions may cause PLEDs and even more, no brain lesionwas identified in some patients. There are many data supporting PLEDs as ictal phenomena. Occurrence of PLEDs usuallyaccompanied by decreased mentality and is improved as PLEDs disappeared. Current SPECT study showed marked hyperperfusionin the lesion side of PLEDs, that is striking evidence of PLEDs as ictal phenomena. Also careful review of EEGwith PLEDs revealed it is a dynamic process rather than a static state. Despite of these evidences, as PLEDs are an end-stageof animal status epilepticus models, it may be a transition of ictal to interictal state.
Key words: Periodic lateralized epileptiform discharges (PLEDs), Status epilepticus, Ictal, Non-ictal
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