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Colchicine Induced Myopathy Presenting Electrophysiologic Myotonia

Ji-Won Yang, Na-Re Kim, Kee Hyung Park
Journal of the Korean Society of Clinical Neurophysiology 2009;11(2):67-70.
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Colchicine is widely used in the treatment of gouty arthritis, and chronic use of colchicine can cause vacuolar myopathy. We report colchicine-induced myopathy with electrophysiological myotonia in a patient with gouty arthritis. A 86-year-old man with gouty arthritis presented with progressive proximal weakness and gait disturbance. Electrophysiological finding showed myotonic myopathy and muscle biopsy revealed a vacuolar myopathy. His symptoms soon resolved with the discontinuation of colchicine.

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