Tetanus is a disorder known to interfere with inhibitory modulation of the motor system in humans. In this report, wedescribe the characteristic neurophysiological findings in a 52-year-old patient with generalized tetanus. The cutaneoussilent period was absent and the silent period evoked in distal upper limb muscles by transcranial magnetic stimulationwas shortened. These findings can be interpreted as evidence of impaired inhibitory mechanisms at multiple levels ofthe nervous system.