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Collet-Sicard Syndrome is one of the variant of the jugular foramen syndromes in which the last four cranial nervesare involved whereas the sympathetic plexus is spared. The possible causes of these multiple lower cranial nerve palsyare variable, including metastasis of systemic malignancy to the base of skull, primary tumor of head and neck, vascularcomplication, trauma and so on. We experienced two men visited to our clinic with symptoms of headache, hoarsness,swallowing difficulty and showed the evidence of cranial nerve palsy on neurologic examination. Magnetic resonanceimaging and computed tomography demonstrated oropharyngeal and hypopharyngeal tumor and electrodiagnostic study supported the diagnosis.