| Testosterone-mediated Neuroprotection in NO Induced CellDeath of Motor Neuron Cells Expressing Wild Typeor Mutant Cu/Zn Superoxide Dismutase |
| Nam Hee Kim, Hyun Jung Kim, Manho Kim, Kyung Seok Park, and Kwang-Woo Lee |
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| Copyright © 2006 The Korean Society of Clinical Neurophysiology |
| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium,
provided the original work is properly cited. |
| ABSTRACT |
Background: Testosterone is reported to have neuroprotective effect in various neurological diseases. Recently, the mechanism involved in nitric oxide (NO)-mediated motor neuron death is under extensive investigation. The Cu/Znsuperoxide dismutase (SOD1) mutations has been implicated in selective motor neuron death of amyotrophic lateral sclerosis (ALS) and it is said to play an important role in NO-mediated motor neuron death. However, neuroprotective effect of testosterone on motor neuron exposed to NO has rarely been studied.
Methods: Motor neuron-neuroblastoma hybrid cells expressing wild-type or mutant (G93A or A4V) SOD gene were treated with 200 |
| Key words:
Amyotrophic lateral sclerosis, Testosterone, Nitric Oxide, Neuroprotection, Cu/Zn superoxide dismutase, Cell viability |
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