| Home | E-Submission | Sitemap | Editorial Office |  
Ann Clin Neurophysiol > Volume 3(2); 2001 > Article
Ann Clin Neurophysiol. 2001; 3(2): 122-127.
The Effect of Acyclovir in Acute Stage of Bell's Palsy
Tae Il Kim, Sang Il Suh, and Dong Kuck Lee
Copyright © 2001 The Korean Society of Clinical Neurophysiology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background : Bell's palsy(BP) is defined as an idiopathic peripheral facial paralysis of sudden onset and account more than 50% of facial paralysis. It's etiology is unclear, but herpes simplex virus type-1 (HSV-1) has been the most suspicious causative agent of BP that over been studied. We evaluated the effect of add-on acyclovir in acute stages of BP. Methods : Subject consisted of 35 patients who developed acute within 10 days after onset of BP. Facial nerve function was assessed by the House-Brackman facial nerve grading scale and facial nerve conduction study including blink reflex. Follow-up evaluation were made 2 month after onset. Twenty of 35 patients were treated with combined therapy of acyclovir and prednisone. As a control group, 15 patients were treated with prednisone only. We compared the improvement of neurologic defects at recovery phase. Results : Compared with two groups, difference in grading scale at recovery phase is statistically significant(p<0.01). So, acyclovir-prednisone group showed a significant improvement in grading at recovery phase compared with prednisone group. Conclusion : We identified the benefit of add-on acyclovir in the acute stage of BP
Key words: Bell's palsy, HSv-1, Acyclovir
Editorial Office
Department of Neurology, Seoul National University (SNU) College of Medicine
SMG-SNU Boramae Medical Center
20 Boramaero-5-Gil, Dongjak-Gu, Seoul 07061, Republic of Korea
TEL : +82-2-2266-7238    FAX : +82-2-831-2826   E-mail: acn.journal@e-acn.org
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Korean Society of Clinical Neurophysiology.           Developed in M2PI