Complex regional pain syndrome (CRPS) is a chronic regional pain disorder that most frequently affects the limbs. It is characterized by hyperalgesia, allodynia, edema, motor disturbance, and vasomotor instability, and typically occurs following surgery or trauma. In type-I CRPS there is no confirmed nerve injury, while peripheral nerve injury is present in type-II CRPS. The multifactorial pathophysiological etiology of CRPS includes inflammation, autoimmune responses, abnormal cytokine production, autonomic dysfunction, altered blood flow, psychological factors, and central cortical reorganization. There are no specific laboratory diagnostic tools for CRPS, and so it is diagnosed clinically. The Budapest criteria are currently the most-accepted diagnostic criteria.
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Complex Regional Pain Syndrome: Updates and Current Evidence Yeng F. Her, Eva Kubrova, Marissa Dombovy-Johnson, Mariam ElSaban, Karson Mostert, Ryan S. D’Souza Current Physical Medicine and Rehabilitation Repor.2024; 12(1): 50. CrossRef
Task-based and Magnified Mirror Therapy for Unilateral Spatial Neglect among post-stroke subjects: Study protocol for a randomized controlled trial Kamal Narayan Arya, Shanta Pandian, Divya Pandey, G. G. Agarwal, Neera Chaudhary, Monika Halicka PLOS ONE.2024; 19(1): e0296276. CrossRef
Diagnosis and Management of Knee Arthrofibrosis and Associated Pain-Related Fear Using Multidimensional Clinical Reasoning and Exposure In Vivo Concept: A Case Report Mohammad Jamali, Kevin McEnroy, Logan W. Gaudette, Zafeer Baber, Ryan J. Stoddard JOSPT Cases.2024; 4(3): 121. CrossRef
Nuclear Imaging in Orthopaedic Practice Alvaro Ibaseta, Ahmed Emara, Ignacio Pasqualini, Benjamin Jevnikar, Ceylan Colak, Oguz Turan, Shujaa T. Khan, Matthew E. Deren, Nicolas S. Piuzzi JBJS Reviews.2024;[Epub] CrossRef
The pathomechanisms involved in both restless legs syndrome (RLS) and complex regional pain syndrome type I(CRPS I) are still controversial whether they are central or peripheral origins. We recently encountered a patient whohad an unusual coexistence of both RLS and CRPS I, and both of which showed good responses to sympathetic block.These findings suggest the role of peripheral mechanisms, especially unmyelinated small autonomic fiber, in both RLSand CRPS I
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