| Jung-Hwan Oh | 6 Articles |
Idiopathic hypertrophic pachymeningitis (IHP) is a rare disease involving localized inflammatory thickening of the intracranial or spinal dura mater without an identified cause. Seizure is a very unusual presentation of IHP. We present a 58-year-old-female patient with seizures caused by IHP. This case indicates that although IHP is rare, it has the potential to cause seizures.
Axonal Charcot-Marie-Tooth disease (CMT2) has most frequently been associated with mutations in the MFN2 gene. MFN2 encodes mitofusin 2, which is a mitochondrial fusion protein that plays an essential role in mitochondrial function. We report CMT2 in a Korean father and his son that manifested with gait difficulties and progressive atrophy of the lower legs. Molecular analysis revealed a novel heterozygous c.2096T>C (p.Leu699Pro) mutation in the exon 18 of MFN2 in both subjects. We suggest that this novel mutation in MFN2 is probably a pathogenic mutation for CMT2.
The most common complaints in patients with OPLL are axial discomforts, which are characterized by dull pain and neck stiffness. Patients with more advanced OPLL develop radiculopathy or compressive myelopathy due to compression of nerve roots or spinal cord. The natural history of the disease is generally chronic static through life, hence prophylactic surgery is rarely recommended. In the OPLL patients with myelopathy, if the symptoms are not serious, the conservative treatment can be considerable.
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Herpes zoster can involve the variable peripheral nervous system but there have been few reports about plexopathy by the herpes zoster. We report a 54-year-old man with left leg weakness soon after herpes zoster in the left leg. His electrophysiological findings were consistent with the left lower lumbosacral plexopathy. It was concluded that herpeszoster can be considered to be one of the rare causes of the lumbosacral plexopathy.
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