Postural orthostatic tachycardia syndrome (POTS) is characterized by increased heart rate with preserved blood pressureon orthostatic stress. Many patients with postural orthostatic tachycardia syndrome can be misdiagnosed as neurosis, chronicfatigue or anxiety disorder. We report a patient with POTS who presented chronic dizziness and fatigue. In approaching toa patient with orthostatic or nonspecific chronic dizziness, the postural heart rate as well as blood pressure should be checkednot to miss the diagnosis.