We report a case of thoracolumbar radiculopathy presented with first symptom of leptomeningeal metastasis. A 65-year old man with non-Hodgkins lymphoma with complete remission was referred for further investigation of dull painand numbness of right lower quadrant of abdomen. Electromyogram revealed right thoracolumbar radiculopathy. Aftertwo weeks, he complained severe continuous bilateral frontal dull headache. An examination of the cerebrospinal fluidrevealed malignant lymphoid cells. We would like to emphasize that radiculopathy sometimes presents with first symptomof leptomeningeal metastasis.