Acute ophthalmoparesis that includes the oculomotor, trochlear, or abducens nerve may occur as an initial presentation of Miller Fisher syndrome (MFS). The symptoms of MFS or variant forms of Guillain-Barre syndrome are pathogenically related to anti-GQ1b antibodies. We report a case of a 36-year-old man with unilateral isolated abducens nerve palsy associated with anti-GM1 antibody. To the best of our knowledge, this is the first report of unilateral isolated abducens nerve palsy with positivity for anti-GM1 immunoglobulin M antibody.

Citations

• Ganglioside (GM1) Immunoglobulin G Antibody Chronic Bilateral Ophthalmoplegia
  Jesse Cheung, Saif Aldeen Alryalat, Osama Al Deyabat, Andrew G. Lee
  Journal of Neuro-Ophthalmology.2025; 45(1): e31.     CrossRef
• Isolated facial diplegia variant of Guillain–Barré syndrome with anti-GM1 IgG antibody
  Jin Ho Jung, Sukyoon Lee, Jung Hwa Seo, Jong Seok Bae, Kyong Jin Shin, Jong Kuk Kim, Byeol-A Yoon, Seong-il Oh
  Annals of Clinical Neurophysiology.2022; 24(1): 17.     CrossRef